iso-ADP ribose

iso-ADP ribose

• CAS Number: 15720-01-1
• UNSPSC Description: iso-ADP ribose (isoADPr) is a ligand used for protein nucleic acid modification. iso-ADP ribose is a structure comprising parts of two consecutive ADP-ribosyl units within the PAR chain. iso-ADP ribose is the small-molecule ligand for RING finger protein 146 (RNF146) WWE. A single iso-ADP ribose molecule triggers the activation of RNF146 by interacting with the basic Lys61 residue in the RING domain[1][2].
• Target Antigen: Fluorescent Dye
• Type: Dye Reagents
• Related Pathways: Others
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/iso-adp-ribose.html
• Smiles: NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O[C@@H]4O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]4O)[C@H](O)[C@@H](COP(O)(O)=O)O3
• Molecular Weight: 559.32
• References & Citations: [1]Kewen Peng, et al. Iso-ADP-Ribose Fluorescence Polarization Probe for the Screening of RNF146 WWE Domain Inhibitors. ACS Chem Biol. 2024 Feb 16;19(2):300-307.|[2]Federico Teloni, et al. Readers of poly(ADP-ribose): designed to be fit for purpose. Nucleic Acids Res. 2016 Feb 18;44(3):993-1006.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported