NF-κB-IN-11
CAT:
804-HY-155998-03
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
NF-κB-IN-11
- CAS Number: 2768833-35-6
- UNSPSC Description: NF-κB-IN-11 (Compound 3i) is a NF-κB inhibitor. NF-κB-IN-11 inhibits TNF-α induced activation of NF-κB pathway, and inhibits nuclear translocation of NF-κB. NF-κB-IN-11 down-regulates the expression levels of phosphor-IKK, IκBα, and NF-κB p65. NF-κB-IN-11 has anti-inflammatory activity, and alleviates dextran sulfate sodium-induced colitis in mice. NF-κB-IN-11 (p.o.) shows a MTD more than 1852 mg/kg in mice acute toxicity assay[1].
- Target Antigen: NF-κB
- Type: Reference compound
- Related Pathways: NF-κB
- Applications: COVID-19-immunoregulation
- Field of Research: Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/nf-κb-in-11.html
- Solubility: DMSO : ≥ 100 mg/mL
- Smiles: O=C(C1=C(C2OC1CC2C#CC3=CC=C(C)C=C3)C(OC)=O)OC
- Molecular Weight: 326.34
- References & Citations: [1]Wu Y, et al. Cantharidin analogue alleviates dextran sulfate sodium-induced colitis in mice by inhibiting the activation of NF-κB signaling. Eur J Med Chem. 2023 Nov 15;260:115731.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported