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Amphotericin B

CAT:
804-HY-B0221-03
Size:
500 mg
Price:
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
Amphotericin B - image 1

Amphotericin B

  • CAS Number: 1397-89-3
  • UNSPSC Description: Amphotericin B is a polyene antifungal agent against a wide variety of fungal pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
  • Target Antigen: Antibiotic; Bacterial; Fungal; Parasite
  • Type: Natural Products
  • Related Pathways: Anti-infection
  • Applications: COVID-19-immunoregulation
  • Field of Research: Infection; Cancer
  • Assay Protocol: https://www.medchemexpress.com/amphotericin-b.html
  • Purity: 98.0
  • Solubility: DMSO : 50 mg/mL (ultrasonic)
  • Smiles: C[C@H]([C@@H](O)[C@@H](C)[C@H](C)OC1=O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](O[C@]2([H])O[C@H](C)[C@@H](O)[C@H](N)[C@@H]2O)C[C@@]3([H])[C@H](C(O)=O)[C@@H](O)C[C@](C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)C1)(O)O3
  • Molecular Weight: 924.08
  • References & Citations: [1]Sau K, et al. The antifungal drug amphotericin B promotes inflammatory cytokine release by a Toll-like receptor- and CD14-dependent mechanism. J Biol Chem. 2003 Sep 26;278(39):37561-8. Epub 2003 Jul 14.|[2]Barwicz J, et al. The effect of aggregation state of amphotericin-B on its interactions with cholesterol- or ergosterol-containing phosphatidylcholine monolayers. Chem Phys Lipids. 1997 Feb 28;85(2):145-55.|[3]Ramos H, et al. Amphotericin B kills unicellular leishmanias by forming aqueous pores permeable to small cations and anions. J Membr Biol. 1996 Jul;152(1):65-75.|[4]Demaimay R, et al. Pharmacological studies of a new derivative of amphotericin B, MS-8209, in mouse and hamster scrapie. J Gen Virol. 1994 Sep;75 (Pt 9):2499-503.|[5]Adams ML, et al. Amphotericin B encapsulated in micelles based on poly(ethylene oxide)-block-poly(L-amino acid) derivatives exerts reduced in vitro hemolysis but maintains potent in vivo antifungal activity. Biomacromolecules. 2003 May-Jun;4(3):750-7.
  • Shipping Conditions: Room Temperature
  • Storage Conditions: 4°C (Powder, protect from light)
  • Clinical Information: Launched