Levamlodipine (besylate)

Levamlodipine (besylate)

• CAS Number: 150566-71-5
• UNSPSC Description: Levamlodipine besylate ((S)-Amlodipine besylate) is an orally active calcium channel blocker with antioxidant and vasodilatory properties. Levamlodipine besylate can reduce serum malondialdehyde (MDA) levels, increase superoxide dismutase (SOD) activity, and improve oxidative stress. Levamlodipine besylate can be used for research on vascular dementia, hypertension, and cerebrovascular diseases[1][2][3][4].
• Target Antigen: Calcium Channel; SOD
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;Membrane Transporter/Ion Channel;Neuronal Signaling
• Applications: COVID-19-immunoregulation
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/Levamlodipine_besylate.html
• Solubility: DMSO : ≥ 150 mg/mL|H2O : ≥ 3.33 mg/mL
• Smiles: O=C(C1=C(COCCN)NC(C)=C(C(OC)=O)[C@@H]1C2=CC=CC=C2Cl)OCC.OS(C3=CC=CC=C3)(=O)=O
• Molecular Weight: 567.05
• References & Citations: [1]Yao KX, et al. Effect of low-dose Levamlodipine Besylate in the treatment of vascular dementia. Sci Rep. 2019 Dec 3;9(1):18248. |[2]Rong H, et al. [Effect of probucol on serum malondialdehyde and superoxide dismutase in patients with primary hypertension]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2012 May;37(5):458-62. |[3]Yang YL, et al. Synergic effects of levamlodipine and bisoprolol on blood pressure reduction and organ protection in spontaneously hypertensive rats. CNS Neurosci Ther. 2012 Jun;18(6):471-4. |[4]Lee YJ, et al. Amlodipine besylate and amlodipine camsylate prevent cortical neuronal cell death induced by oxidative stress. J Neurochem. 2011 Dec;119(6):1262-70.
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• Clinical Information: Launched