PAC-1
CAT:
804-HY-13523-05
Size:
100 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PAC-1
- CAS Number: 315183-21-2
- UNSPSC Description: PAC-1 is a procaspase-3 activator that induces apoptosis in cancer cells with an EC50 of 2.08 μM.
- Target Antigen: Apoptosis; Autophagy; Caspase
- Type: Reference compound
- Related Pathways: Apoptosis;Autophagy
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/PAC-1.html
- Smiles: O=C(N/N=C/C1=CC=CC(CC=C)=C1O)CN2CCN(CC3=CC=CC=C3)CC2
- Molecular Weight: 392.49
- References & Citations: [1]Wang F, et al. A novel small-molecule activator of procaspase-3 induces apoptosis in cancer cells and reduces tumor growth in human breast, liver and gallbladder cancer xenografts. Mol Oncol. 2014 Dec;8(8):1640-52.|[2]Seervi M, et al. ERO1α-dependent endoplasmic reticulum-mitochondrial calcium flux contributes to ER stress and mitochondrial permeabilization by procaspase-activating compound-1 (PAC-1). Cell Death Dis. 2013 Dec 19;4:e968.|[3]Putt KS, et al. Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat Chem Biol. 2006 Oct;2(10):543-50.
- Shipping Conditions: Room Temperature