3-(2-Hydroxyethyl) thio withaferin A
CAT:
804-HY-N10358
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
3-(2-Hydroxyethyl) thio withaferin A
- UNSPSC Description: 3-(2-Hydroxyethyl) thio withaferin A is a Withaferin A derivative. Withaferin A, a steroidal lactone, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding[1][2][3].
- Target Antigen: NF-κB
- Type: Natural Products
- Related Pathways: NF-κB
- Field of Research: Others
- Assay Protocol: https://www.medchemexpress.com/3-2-hydroxyethyl-thio-withaferin-a.html
- Solubility: 10 mM in DMSO
- Smiles: C[C@H](C1OC(C(CO)=C(C)C1)=O)C2CCC3C4C[C@@H]5[C@]([C@@]6(C)C4CC[C@@]32C)(O5)[C@@H](O)[C@@H](SCCO)CC6=O
- Molecular Weight: 548.73
- References & Citations: [1]Kaileh M, et al. Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity. J Biol Chem. 2007 Feb 16;282(7):4253-64. Epub 2006 Dec 6.|[2]Bargagna-Mohan P, et al. The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin. Chem Biol. 2007 Jun;14(6):623-34.|[3]Kakar SS, et al. Withaferin A (WFA) inhibits tumor growth and metastasis by targeting ovarian cancer stem cells. Oncotarget. 2017 Aug 10;8(43):74494-74505.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported