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3-(2-Hydroxyethyl) thio withaferin A

CAT:
804-HY-N10358
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
3-(2-Hydroxyethyl) thio withaferin A - image 1

3-(2-Hydroxyethyl) thio withaferin A

  • UNSPSC Description: 3-(2-Hydroxyethyl) thio withaferin A is a Withaferin A derivative. Withaferin A, a steroidal lactone, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding[1][2][3].
  • Target Antigen: NF-κB
  • Type: Natural Products
  • Related Pathways: NF-κB
  • Field of Research: Others
  • Assay Protocol: https://www.medchemexpress.com/3-2-hydroxyethyl-thio-withaferin-a.html
  • Solubility: 10 mM in DMSO
  • Smiles: C[C@H](C1OC(C(CO)=C(C)C1)=O)C2CCC3C4C[C@@H]5[C@]([C@@]6(C)C4CC[C@@]32C)(O5)[C@@H](O)[C@@H](SCCO)CC6=O
  • Molecular Weight: 548.73
  • References & Citations: [1]Kaileh M, et al. Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity. J Biol Chem. 2007 Feb 16;282(7):4253-64. Epub 2006 Dec 6.|[2]Bargagna-Mohan P, et al. The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin. Chem Biol. 2007 Jun;14(6):623-34.|[3]Kakar SS, et al. Withaferin A (WFA) inhibits tumor growth and metastasis by targeting ovarian cancer stem cells. Oncotarget. 2017 Aug 10;8(43):74494-74505.
  • Shipping Conditions: Room temperature
  • Clinical Information: No Development Reported