H-Leu-Ser-Lys-Leu-OH

H-Leu-Ser-Lys-Leu-OH

• CAS Number: 162559-45-7
• UNSPSC Description: H-Leu-Ser-Lys-Leu-OH (LSYL) is a latency-associated peptide at the amino terminus of LAP, with inhibitory effect on TGF-β1 activation. H-Leu-Ser-Lys-Leu-OH, binding with KRFK (HY-P3970), can block the signal transduction of TGF-β1, and prevent the progression of hepatic damage and fibrosis[1].
• Target Antigen: TGF-beta/Smad
• Type: Peptides
• Related Pathways: Stem Cell/Wnt;TGF-beta/Smad
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/h-leu-ser-lys-leu-oh.html
• Solubility: 10 mM in DMSO
• Smiles: CC(C)C[C@@H](C(O)=O)NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CC(C)C)N)=O)=O)=O
• Molecular Weight: 459.58
• References & Citations: [1]Kondou H, et al. A blocking peptide for transforming growth factor-beta1 activation prevents hepatic fibrosis in vivo. J Hepatol. 2003 Nov;39(5):742-8.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported