Heptamidine (dimethanesulfonate)

Heptamidine (dimethanesulfonate)

• CAS Number: 161374-55-6
• UNSPSC Description: Heptamidine dimethanesulfonate (SBi4211 dimethanesulfonate) is a potent Pentamidine-related inhibitor of the calcium-binding protein S100B (Kd=6.9 μM), selectively kills melanoma cells with S100B over those without S100B[1]. Heptamidine is a useful tool for the investigation of Myotonic dystrophy (DM)[2].
• Target Antigen: Others
• Type: Reference compound
• Related Pathways: Others
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/heptamidine-dimethanesulfonate.html
• Solubility: DMSO : 62.5 mg/mL (ultrasonic)
• Smiles: N=C(C1=CC=C(OCCCCCCCOC2=CC=C(C(N)=N)C=C2)C=C1)N.CS(=O)(O)=O.CS(=O)(O)=O
• Molecular Weight: 560.68
• References & Citations: [1]McKnight LE, et al. Structure-Based Discovery of a Novel Pentamidine-Related Inhibitor of the Calcium-Binding Protein S100B. ACS Med Chem Lett. 2012 Dec 13;3(12):975-979. Epub 2012 Sep 25.|[2]Coonrod LA, et al. Reducing levels of toxic RNA with small molecules.ACS Chem Biol. 2013 Nov 15;8(11):2528-37.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported