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Heptamidine (dimethanesulfonate)

CAT:
804-HY-16918A-05
Size:
50 mg
Price:
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
Heptamidine (dimethanesulfonate) - image 1

Heptamidine (dimethanesulfonate)

  • CAS Number: 161374-55-6
  • UNSPSC Description: Heptamidine dimethanesulfonate (SBi4211 dimethanesulfonate) is a potent Pentamidine-related inhibitor of the calcium-binding protein S100B (Kd=6.9 μM), selectively kills melanoma cells with S100B over those without S100B[1]. Heptamidine is a useful tool for the investigation of Myotonic dystrophy (DM)[2].
  • Target Antigen: Others
  • Type: Reference compound
  • Related Pathways: Others
  • Applications: COVID-19-immunoregulation
  • Field of Research: Cancer; Inflammation/Immunology
  • Assay Protocol: https://www.medchemexpress.com/heptamidine-dimethanesulfonate.html
  • Solubility: DMSO : 62.5 mg/mL (ultrasonic)
  • Smiles: N=C(C1=CC=C(OCCCCCCCOC2=CC=C(C(N)=N)C=C2)C=C1)N.CS(=O)(O)=O.CS(=O)(O)=O
  • Molecular Weight: 560.68
  • References & Citations: [1]McKnight LE, et al. Structure-Based Discovery of a Novel Pentamidine-Related Inhibitor of the Calcium-Binding Protein S100B. ACS Med Chem Lett. 2012 Dec 13;3(12):975-979. Epub 2012 Sep 25.|[2]Coonrod LA, et al. Reducing levels of toxic RNA with small molecules.ACS Chem Biol. 2013 Nov 15;8(11):2528-37.
  • Shipping Conditions: Room Temperature
  • Clinical Information: No Development Reported