VX-11e
CAT:
804-HY-14178-06
Size:
100 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
VX-11e
- CAS Number: 896720-20-0
- UNSPSC Description: VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK with Ki < 2 nM.
- Target Antigen: ERK
- Type: Reference compound
- Related Pathways: MAPK/ERK Pathway;Stem Cell/Wnt
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/VX-11e.html
- Solubility: DMSO : ≥ 100 mg/mL
- Smiles: FC1=CC(Cl)=C(NC2=NC(C3=CNC(C(N[C@H](CO)C4=CC=CC(Cl)=C4)=O)=C3)=C(C)C=N2)C=C1
- Molecular Weight: 500.35
- References & Citations: [1]Aronov, Alex M., et al. Structure-Guided Design of Potent and Selective Pyrimidylpyrrole Inhibitors of Extracellular Signal-Regulated Kinase (ERK) Using Conformational Control. Journal of Medicinal Chemistry (2009), 52(20), 6362-6368.|[2]Krepler C, et al. Personalized Preclinical Trials in BRAF Inhibitor-Resistant Patient-Derived Xenograft Models Identify Second-Line Combination Therapies. Clin Cancer Res. 2016 Apr 1;22(7):1592-602.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported