Anti-inflammatory agent 35

Anti-inflammatory agent 35

• CAS Number: 9007-83-4
• UNSPSC Description: Anti-inflammatory agent 35 (compound 5a27) is an orally active curcumin analogue with anti-inflammatory activity. Anti-inflammatory agent 35 blocks mitogen-activated protein kinase (MAPK) signaling and p65 nuclear translocation of NF-kB. Anti-inflammatory agent 35 also inhibits yellow neutrophil infiltration and pro-inflammatory cytokine production. Anti-inflammatory agent 35 significantly attenuates lipopolysaccharide (LPS)-induced acute lung injury (ALI) in vivo[1].
• Target Antigen: ERK; Interleukin Related; NF-κB; p38 MAPK; TNF Receptor
• Type: Reference compound
• Related Pathways: Apoptosis;Immunology/Inflammation;MAPK/ERK Pathway;NF-κB;Stem Cell/Wnt
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/anti-inflammatory-agent-35.html
• Solubility: DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: CC(OC1=CC=C(/C=C/C(N2C(/C(CCC2)=C/C3=CC(OC)=C(OC)C(OC)=C3)=O)=O)C=C1OC)=O
• Molecular Weight: 495.52
• References & Citations: [1]Qian J, et al. Design and synthesis novel di-carbonyl analogs of curcumin (DACs) act as potent anti-inflammatory agents against LPS-induced acute lung injury (ALI). Eur J Med Chem. 2019 Apr 1;167:414-425.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported