SGI-1776 (free base)
CAT:
804-HY-13287-04
Size:
50 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
SGI-1776 (free base)
- CAS Number: 1025065-69-3
- UNSPSC Description: SGI-1776 free base is an inhibitor of Pim kinases, with IC50s of 7 nM, 363 nM, and 69 nM for Pim-1, -2 and -3, respectively.
- Target Antigen: Apoptosis; Autophagy; Pim
- Type: Reference compound
- Related Pathways: Apoptosis;Autophagy;JAK/STAT Signaling
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/sgi-1776-free-base.html
- Purity: 99.23
- Solubility: DMSO : 125 mg/mL (ultrasonic)
- Smiles: CN1CCC(CC1)CNC2=NN3C(C=C2)=NC=C3C4=CC=CC(OC(F)(F)F)=C4
- Molecular Weight: 405.42
- References & Citations: [1]Hou X, et al. Biochemical changes of salivary gland adenoid cystic carcinoma cells induced by SGI-1776. Exp Cell Res. 2017 Mar 15;352(2):403-411.|[2]Park YK, et al. The novel anti-adipogenic effect and mechanisms of action of SGI-1776, a Pim-specific inhibitor, in 3T3-L1 adipocytes. Int J Mol Med. 2016 Jan;37(1):157-64|[3]Xie J, et al. SGI-1776, an imidazo pyridazine compound, inhibits the proliferation of ovarian cancer cells by inactivating Pim-1. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2014 Jul;39(7):649-57|[4]Chen LS, et al. Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia. Blood, 2011, 118(3), 693-702.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: Phase 1