JY-XHe-053

JY-XHe-053

• CAS Number: 612526-36-0
• UNSPSC Description: JY-XHe-053 is a potent and selective agonist of GABAA receptors containing the α5 subunit (Kis of 22.0 nM, 12.3 nM, 34.9 nM, 0.7 nM for α1, α2, α3, α5, respectively). JY-XHe-053 lacks significant anti-anxiety activity, despite its efficacy at α2- and α3-GABAA receptors[1][2].
• Target Antigen: GABA Receptor
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
• Assay Protocol: https://www.medchemexpress.com/jy-xhe-053.html
• Smiles: O=C(OCC)C1=C2CN=C(C3=CC(C#C)=CC=C3N2C=N1)C4=CC=CC=C4F
• Molecular Weight: 373.38
• References & Citations: [1]Rivas FM, Stables JP, Murphree L, et al. Antiseizure activity of novel gamma-aminobutyric acid (A) receptor subtype-selective benzodiazepine analogues in mice and rat models. J Med Chem. 2009;52(7):1795-1798. |[2]Savić MM, Majumder S, Huang S, et al. Novel positive allosteric modulators of GABAA receptors: do subtle differences in activity at alpha1 plus alpha5 versus alpha2 plus alpha3 subunits account for dissimilarities in behavioral effects in rats?. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(2):376-386.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported