TP-060
CAT:
804-HY-144266-05
Size:
50 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
TP-060
- CAS Number: 2601393-20-6
- UNSPSC Description: Glucosylceramide synthase-IN-1 (T-036) a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 31 nM and 51 nM for human GCS and mouse GCS, respectively. Glucosylceramide synthase-IN-1 can be used for Gaucher's disease research[1].
- Target Antigen: Glucosylceramide Synthase (GCS)
- Type: Reference compound
- Related Pathways: Neuronal Signaling
- Applications: Metabolism-protein/nucleotide metabolism
- Field of Research: Metabolic Disease; Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/tp-060.html
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: FC1=CC(OCC(F)(F)F)=C(C2=NC=CC3=C2CN(C4=CC=C(C(C)(O)C)C=C4)C3=O)C=C1
- Molecular Weight: 460.42
- References & Citations: [1]Yuta Tanaka, et al. Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore. J Med Chem. 2022 Mar 10;65(5):4270-4290
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported