Fumaric acid

Fumaric acid

• CAS Number: 110-17-8
• UNSPSC Description: Fumaric acid is an unsaturated dicarbonic acid, an intermediate product of the citric acid cycle that provides intracellular energy in the form of ATP. Fumaric acid exerts anti-inflammatory effects by inhibiting the NF-κB signaling pathway dependent on p38 MAPK. Fumaric acid can be used in the study of pregnancy-induced hypertension[1][2][3].
• Target Antigen: Endogenous Metabolite; NF-κB; p38 MAPK
• Type: Natural Products
• Related Pathways: MAPK/ERK Pathway;Metabolic Enzyme/Protease;NF-κB
• Applications: Cancer-programmed cell death
• Field of Research: Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/Fumaric_acid.html
• Purity: 99.85
• Solubility: DMSO : 25 mg/mL (ultrasonic)|H2O : 11.11 mg/mL (ultrasonic)
• Smiles: O=C(O)/C=C/C(O)=O
• Molecular Weight: 116.07
• References & Citations: [1]Whelan DT, et al. Fumaric aciduria: a new organic aciduria, associated with mental retardation and speech impairment. Clin Chim Acta. 1983 Aug 31;132(3):301-8.|[2]Roh KB, et al. Fumaric acid attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Food Chem Toxicol. 2013 Aug;58:423-31.|[3]Zhou Y, et al. Fumaric acid and succinic acid treat gestational hypertension by downregulating the expression of KCNMB1 and TET1. Exp Ther Med. 2021 Oct;22(4):1072.
• Shipping Conditions: Room Temperature
• Storage Conditions: Store at room temperature 3 years
• Clinical Information: Launched