TPA-dT

TPA-dT

• UNSPSC Description: TPA-dT is a thymidine analog with a tris[(2-pyridyl)methyl]amine (TPA) group. TPA-dT can be used to modify siRNAs. The TPA-modified siRNAs remain functionally inactive and is incapable of silencing gene expression until the TPA moiety is removed upon exposure to Cu(I)[1].
• Target Antigen: Small Interfering RNA (siRNA)
• Type: Reference compound
• Related Pathways: Epigenetics
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/tpa-dt.html
• Solubility: 10 mM in DMSO
• Smiles: O[C@H]1C[C@H](N2C(N=C(OCC3=CC=CC(CN(CC4=NC=CC=C4)CC5=NC=CC=C5)=N3)C(C)=C2)=O)O[C@@H]1CO
• Molecular Weight: 544.60
• References & Citations: [1]Morihiro K, et al. Copper-mediated siRNA activation for conditional control of gene expression. Bioorg Med Chem Lett. 2024 May 15;104:129738.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported