TPA-dT
CAT:
804-HY-161436
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
TPA-dT
- UNSPSC Description: TPA-dT is a thymidine analog with a tris[(2-pyridyl)methyl]amine (TPA) group. TPA-dT can be used to modify siRNAs. The TPA-modified siRNAs remain functionally inactive and is incapable of silencing gene expression until the TPA moiety is removed upon exposure to Cu(I)[1].
- Target Antigen: Small Interfering RNA (siRNA)
- Type: Reference compound
- Related Pathways: Epigenetics
- Field of Research: Others
- Assay Protocol: https://www.medchemexpress.com/tpa-dt.html
- Solubility: 10 mM in DMSO
- Smiles: O[C@H]1C[C@H](N2C(N=C(OCC3=CC=CC(CN(CC4=NC=CC=C4)CC5=NC=CC=C5)=N3)C(C)=C2)=O)O[C@@H]1CO
- Molecular Weight: 544.60
- References & Citations: [1]Morihiro K, et al. Copper-mediated siRNA activation for conditional control of gene expression. Bioorg Med Chem Lett. 2024 May 15;104:129738.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported