MERS-CoV-IN-2
CAT:
804-HY-162674
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
MERS-CoV-IN-2
- UNSPSC Description: MERS-CoV-IN-2 (compound 3c) is a MERS-CoV 3CLpro inhibitor (IC50=17nM). MERS-CoV-IN-2 inhibits the activity of the 3CLpro enzyme by binding to the active site of the enzyme, specifically the S4 subsite, thereby exhibiting antiviral activity against SARS-CoV-2 and MERS-CoV[1].
- Target Antigen: SARS-CoV
- Type: Reference compound
- Related Pathways: Anti-infection
- Field of Research: Infection
- Assay Protocol: https://www.medchemexpress.com/mers-cov-in-2.html
- Smiles: O=C(N[C@H](C(N[C@H](C=O)C[C@H]1C(NCC1)=O)=O)CC(C)C)OC[C@@H](N2CC3=CC=CC(Cl)=C3)CCC2=O
- Molecular Weight: 535.03
- References & Citations: [1]Dampalla, et al. Structure-Guided Design of Potent Coronavirus Inhibitors with a 2-Pyrrolidone Scaffold: Biochemical, Crystallographic, and Virological Studies. Journal of Medicinal Chemistry (2024).
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported