Rocuronium (Bromide)

Rocuronium (Bromide)

• CAS Number: 119302-91-9
• UNSPSC Description: Rocuronium Bromide (ORG 9426 Bromide) is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal musclerelaxation during surgery or mechanical ventilation.
• Target Antigen: nAChR
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease; Cancer
• Assay Protocol: https://www.medchemexpress.com/rocuronium-bromide.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
• Smiles: C[C@@]12[C@](C[C@H]([N+]3(CC=C)CCCC3)[C@@H]2OC(C)=O)([H])[C@]([C@]4([H])CC1)([H])CC[C@@]([C@]4(C)C5)([H])C[C@H](O)[C@H]5N6CCOCC6.[Br-]
• Molecular Weight: 609.68
• References & Citations: [1]Narimatsu E, Niiya T, Takahashi K, Pralidoxime inhibits paraoxon-induced depression of rocuronium-neuromuscular block in a time-dependentfashion. Am J Emerg Med. 2012 Jul;30(6):901-7.|[2]Wicks TC. The pharmacology of rocuronium bromide (ORG 9426). AANA J. 1994 Feb;62(1):33-8.|[3]Wierda JM, Kleef UW, Lambalk LM, The pharmacodynamics and pharmacokinetics of Org 9426, a new non-depolarizing neuromuscular blocking agent, in patients anaesthetized with nitrous oxide, halothane and fentanyl. Can J Anaesth. 1991 May;38(4 Pt 1):430-5.|[4]Khuenl-Brady K, Castagnoli KP, Canfell PC, The neuromuscular blocking effects and pharmacokinetics of ORG 9426 and ORG 9616 in the cat. Anesthesiology. 1990 Apr;72(4):669-74.Sci Rep. 2017 Apr 5;7:46098.|Hum Mol Genet. 2015 Aug 15;24(16):4648-59.
• Shipping Conditions: Room Temperature
• Clinical Information: Launched