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STAT6-IN-3

CAT:
804-HY-153992-06
Size:
50 mg
Price:
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
STAT6-IN-3 - image 1

STAT6-IN-3

  • CAS Number: 371919-80-1
  • UNSPSC Description: STAT6-IN-3 (Compound 18a) is a STAT6 inhibitor (IC50= 44 nM). STAT6-IN-3 targets the Src Homology 2 (SH2) domain of STAT6. STAT6-IN-3 can be used for research of inflammation such as asthma[1].
  • Target Antigen: STAT
  • Type: Reference compound
  • Related Pathways: JAK/STAT Signaling;Stem Cell/Wnt
  • Applications: COVID-19-immunoregulation
  • Field of Research: Inflammation/Immunology
  • Assay Protocol: https://www.medchemexpress.com/stat6-in-3.html
  • Solubility: DMSO : 100 mg/mL (ultrasonic)
  • Smiles: O=C(/C=C/C1=CC=C(C=C1)OP(O)(O)=O)N[C@H](C(N2CCC[C@H]2C(N(C3=CC=C(C=C3)I)C4=CC=CC=C4)=O)=O)C(C)(C)C
  • Molecular Weight: 731.51
  • References & Citations: [1]Mandal PK, et al. Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity. J Med Chem. 2015 Nov 25;58(22):8970-84.
  • Shipping Conditions: Room Temperature
  • Clinical Information: No Development Reported