Tizoxanide-d4
CAT:
804-HY-12687S-01
Size:
1 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Tizoxanide-d4
- CAS Number: 1246817-56-0
- UNSPSC Description: Tizoxanide-d4 is the deuterium labeled Tizoxanide. Tizoxanide is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide has anti-HIV-1 activities[1][2].
- Target Antigen: Autophagy; Bacterial; HIV; Isotope-Labeled Compounds
- Type: Isotope-Labeled Compounds
- Related Pathways: Anti-infection;Autophagy;Others
- Field of Research: Infection
- Purity: 99.79
- Solubility: 10 mM in DMSO
- Smiles: O=[N+]([O-])C1=CN=C(S1)NC(C2=C(C([2H])=C([2H])C([2H])=C2[2H])O)=O
- Molecular Weight: 269.27
- References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Korba BE, et al. Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication.
 Antiviral Res. 2008 Jan;77(1):56-63.|[3]Ashton LV, et al. In Vitro Susceptibility of Canine Influenza A (H3N8) Virus to Nitazoxanide and Tizoxanide. Vet Med Int. 2010 Aug 12;2010. pii: 891010.|[4]Korba BE, et al. Potential for hepatitis C virus resistance to nitazoxanide or tizoxanide. Antimicrob Agents Chemother. 2008 Nov;52(11):4069-71.|[5]Trabattoni D, et al. Thiazolides Elicit Anti-Viral Innate Immunity and Reduce HIV Replication. Sci Rep. 2016 Jun 2;6:27148.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture and light)
- Clinical Information: No Development Reported