5-Fluoro-2'-deoxycytidine
CAT:
804-HY-116217-05
Size:
50 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
5-Fluoro-2'-deoxycytidine
- CAS Number: 10356-76-0
- UNSPSC Description: 5-Fluoro-2'-deoxycytidine, a fluoropyrimidine nucleoside analogue, is a DNA methyltransferase (DNMT) inhibitor. 5-Fluoro-2'-deoxycytidine is a tumor-selective proagent of the potent thymidylate synthase inhibitor 5-fluoro-2′-dUMP[1][2].
- Target Antigen: DNA Methyltransferase
- Type: Reference compound
- Related Pathways: Epigenetics
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/5-fluoro-2-deoxycytidine.html
- Purity: 99.87
- Solubility: DMSO : 50 mg/mL (ultrasonic)|H2O : 16.67 mg/mL (ultrasonic)
- Smiles: O[C@H]1C[C@H](N2C(N=C(N)C(F)=C2)=O)O[C@@H]1CO
- Molecular Weight: 245.21
- References & Citations: [1]Beumer JH, et, al. Pharmacokinetics, metabolism, and oral bioavailability of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine in mice. Clin Cancer Res. 2006 Dec 15;12(24):7483-91.|[2]Osterman DG, et, al. 5-Fluorocytosine in DNA is a mechanism-based inhibitor of HhaI methylase. Biochemistry. 1988 Jul 12;27(14):5204-10.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, protect from light)
- Clinical Information: Phase 2