Maleimido-tri(ethylene glycol)-propionic acid

Maleimido-tri(ethylene glycol)-propionic acid

• Product Name Alternative: Mal-PEG3-acid
• CAS Number: 518044-40-1
• UNSPSC Description: Maleimido-tri(ethylene glycol)-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Maleimido-tri(ethylene glycol)-propionic acid is used for the preparation of neolymphostin-based ADC precursors for site-specific cysteine mutant trastuzumab-A114C conjugation[1]. Maleimido-tri(ethylene glycol)-propionic acid also can be used as a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
• Target Antigen: ADC Linker; PROTAC Linkers
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related;PROTAC
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/maleimido-tri-ethylene-glycol-propionic-acid.html
• Purity: 99.14
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(O)CCOCCOCCOCCN1C(C=CC1=O)=O
• Molecular Weight: 301.29
• References & Citations: [1]Zhou D,et al. Novel PIKK inhibitor antibody-drug conjugates: Synthesis and anti-tumor activity.Bioorg Med Chem Lett. 2019 Apr 1;29(7):943-947.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported