Carboxy pyridostatin (trifluoroacetate salt)

Carboxy pyridostatin (trifluoroacetate salt)

• CAS Number: 2444713-88-4
• UNSPSC Description: Carboxy pyridostatin trifluoroacetate salt is a G-quadruplex ligand that has a highly molecular specificity to RNA on DNA G4s, and can reduce the proliferation of adult neural stem cells and progenitor cells derived from the subventricular zone of adult mice in vitro and in vivo[1][2].
• Target Antigen: G-quadruplex
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Neuroscience-Neuromodulation
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/Carboxy_pyridostatin_trifluoroacetate_salt.html
• Purity: 99.13
• Solubility: DMSO : 100 mg/mL (ultrasonic)|H2O : 60 mg/mL (ultrasonic)
• Smiles: O=C(O)CCN1N=NC(COC2=CC(C(NC3=NC4=CC=CC=C4C(OCCN)=C3)=O)=NC(C(NC5=NC6=CC=CC=C6C(OCCN)=C5)=O)=C2)=C1.FC(C(O)=O)(F)F
• Molecular Weight: 820.73
• References & Citations: [1]Rocca R, et al. Molecular recognition of a carboxy pyridostatin toward G-quadruplex structures: Why does it prefer RNA? Chem Biol Drug Des. 2017 Nov;90(5):919-925.|[2]Goldberg DC, et al. Manipulating Adult Neural Stem and Progenitor Cells with G-Quadruplex Ligands. ACS Chem Neurosci. 2020;11(10):1504-1518.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported