Prochloraz

Prochloraz

• CAS Number: 67747-09-5
• UNSPSC Description: Prochloraz is an imidazole antifungal. Prochloraz is as an estrogen receptor (ER) and androgen receptor (AR) antagonist and an aromatase inhibitor with IC50 values of 25 μM, 4 μM and 0.3 μM, respectively. Prochloraz is able to activate the aryl hydrocarbon receptor (AhR) having an EC50 of 1 μM[1][2].
• Target Antigen: Androgen Receptor; Aryl Hydrocarbon Receptor; Estrogen Receptor/ERR; Fungal
• Type: Reference compound
• Related Pathways: Anti-infection;Immunology/Inflammation;Vitamin D Related/Nuclear Receptor
• Applications: COVID-19-immunoregulation
• Field of Research: Infection; Endocrinology
• Assay Protocol: https://www.medchemexpress.com/prochloraz.html
• Purity: 99.77
• Solubility: DMSO : 250 mg/mL (ultrasonic)
• Smiles: O=C(N1C=CN=C1)N(CCC)CCOC2=C(Cl)C=C(Cl)C=C2Cl
• Molecular Weight: 376.67
• References & Citations: [1]E Antignac, et al. Prochloraz as potent inhibitor of benzo[a]pyrene metabolism and mutagenic activity in rat liver fractions. Toxicol Lett. 1990 Dec;54(2-3):309-15.|[2]Anne Marie Vinggaard, et al. Prochloraz: an imidazole fungicide with multiple mechanisms of action. Int J Androl. 2006 Feb;29(1):186-92.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported