Thalidomide-propargyl
CAT:
804-HY-126457-05
Size:
100 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Thalidomide-propargyl
- CAS Number: 2098487-39-7
- UNSPSC Description: Thalidomide-propargyl is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-propargyl can be connected to the ligand for protein by a linker to form the IMiD containing PROTACs[1]. Thalidomide-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Target Antigen: Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
- Type: Reference compound
- Related Pathways: Apoptosis;Autophagy;PROTAC
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/thalidomide-propargyl.html
- Purity: 99.97
- Solubility: DMSO : 16.67 mg/mL (ultrasonic)
- Smiles: O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCC#C)=O
- Molecular Weight: 312.281
- References & Citations: [1]Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported