Stearoyl Serotonin
CAT:
804-HY-121465
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Stearoyl Serotonin
- CAS Number: 67964-87-8
- UNSPSC Description: Stearoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin. Arachidonoyl serotonin is a dual antagonist of fatty acid amide hydrolase (FAAH) and the transient receptor potential vanilloid-type 1 (TRPV1) channel, reducing both acute and chronic peripheral pain. The effects of replacing the arachidonoyl portion with the saturated 18-carbon stearoyl moiety have not been studied. However, replacement of arachidonate with saturated 11- or 12-carbon fatty acids produces compounds that potently inhibit capsaicin-induced TRPV1 channel activation (IC50=0.76 μM) without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine (IC50 > 50 μM).
- Target Antigen: Endogenous Metabolite
- Type: Reference compound
- Related Pathways: Metabolic Enzyme/Protease
- Applications: Metabolism-protein/nucleotide metabolism
- Field of Research: Metabolic Disease
- Assay Protocol: https://www.medchemexpress.com/stearoyl-serotonin.html
- Smiles: O=C(CCCCCCCCCCCCCCCCC)NCCC1=CNC2=CC=C(C=C12)O
- Molecular Weight: 442.68
- References & Citations: [1]Ortar, et al. New N-arachidonoylserotonin analogues with potential \"dual\" mechanism of action against pain. J. Med. Chem. 50(26), 6554-6569 (2007).
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported