Phenazine (methylsulfate)

Phenazine (methylsulfate)

• CAS Number: 299-11-6
• UNSPSC Description: Phenazine methylsulfate is a free radical generator that can act as an electron transfer reactant in cell viability assays. It also has insecticidal properties. Furthermore, Phenazine methylsulfate induces oxidative DNA damage and cell apoptosis, showing antitumor activity[1][2][3].
• Target Antigen: Antibiotic; Apoptosis; Bacterial
• Type: Reference compound
• Related Pathways: Anti-infection;Apoptosis
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/phenazine-methylsulfate.html
• Purity: 98.0
• Solubility: DMSO : 100 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
• Smiles: C[N+]1=C2C=CC=CC2=NC3=C1C=CC=C3.O=S(OC)([O-])=O
• Molecular Weight: 306.343
• References & Citations: [1]G E Edwards, et al. Action of phenazine methyl sulfate, inhibitors, and uncouplers on the light-induced proton transport by cells ofRhodospirillum rubrum. J Membr Biol. 1970 Dec;2(1):95-107.|[2]Anh B Hua, et al. Repurposing the Electron Transfer Reactant Phenazine Methosulfate (PMS) for the Apoptotic Elimination of Malignant Melanoma Cells through Induction of Lethal Oxidative and Mitochondriotoxic Stress. Cancers (Basel). 2019 Apr 27;11(5):590.|[3]E Pontiki, et al. Evaluation of anti-inflammatory and antioxidant activities of copper (II) Schiff mono-base and copper(II) Schiff base coordination compounds of dien with heterocyclic aldehydes and 2-amino-5-methyl-thiazole. J Enzyme Inhib Med Chem. 2008 Dec;23(6):1011-7.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture and light)
• Clinical Information: Launched