Ergothioneine

Ergothioneine

• CAS Number: 497-30-3
• UNSPSC Description: Ergothioneine is an imidazole-2-thione derivative with orally active histidine betaine. Ergothioneine is a specific inhibitor of p38-MAPK and Akt, which plays a protective role in cell apoptosis induced by stress. Ergothioneine has antioxidant activity[1][2].
• Target Antigen: Akt; Endogenous Metabolite; Keap1-Nrf2; NF-κB; p38 MAPK
• Type: Natural Products
• Related Pathways: MAPK/ERK Pathway;Metabolic Enzyme/Protease;NF-κB;PI3K/Akt/mTOR
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/ergothioneine.html
• Purity: 99.99
• Solubility: H2O : 125 mg/mL (ultrasonic)
• Smiles: S=C1NC(C[C@@H](C([O-])=O)[N+](C)(C)C)=CN1
• Molecular Weight: 229.305
• References & Citations: [1]Colognato R, et al. Modulation of hydrogen peroxide-induced DNA damage, MAPKs activation and cell death in PC12 by ergothioneine. Clin Nutr. 2006 Feb;25(1):135-45.|[2]Salama SA, et al. Ergothioneine mitigates cisplatin-evoked nephrotoxicity via targeting Nrf2, NF-κB, and apoptotic signaling and inhibiting γ-glutamyl transpeptidase. Life Sci. 2021 Aug 1;278:119572.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, sealed storage, away from moisture)
• Clinical Information: Phase 3