Methylprednisolone

Methylprednisolone

• CAS Number: 83-43-2
• UNSPSC Description: Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels[3].
• Target Antigen: Autophagy; Bacterial; Glucocorticoid Receptor; SARS-CoV
• Type: Reference compound
• Related Pathways: Anti-infection;Autophagy;Immunology/Inflammation;Vitamin D Related/Nuclear Receptor
• Applications: COVID-19-anti-virus
• Field of Research: Cancer; Infection; Endocrinology; Inflammation/Immunology; Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/methylprednisolone.html
• Purity: 99.75
• Solubility: DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : < 0.1 mg/mL (ultrasonic)
• Smiles: O=C1C=C[C@]2(C)[C@@]3([H])[C@@H](O)C[C@]4(C)[C@@](O)(C(CO)=O)CC[C@@]4([H])[C@]3([H])C[C@H](C)C2=C1
• Molecular Weight: 374.47
• References & Citations: [1]Strupp, M., et al., Methylprednisolone, valacyclovir, or the combination for vestibular neuritis. N Engl J Med, 2004. 351(4): p. 354-61.|[2]Bracken, M.B., et al., A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study. N Engl J Med, 1990. 322(20): p. 1405-11.|[3]Zhen Xiang, et al. Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels. Int J Biol Sci 2020; 16(13):2382-2391.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, protect from light)
• Clinical Information: Launched