Pilocarpine

Pilocarpine

• CAS Number: 92-13-7
• UNSPSC Description: Pilocarpine is a selective M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.
• Target Antigen: mAChR
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease; Cancer
• Assay Protocol: https://www.medchemexpress.com/pilocarpine.html
• Purity: 99.89
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C1OC[C@H](CC2=CN=CN2C)[C@@H]1CC
• Molecular Weight: 208.26
• References & Citations: [1]Matsuzaki K, et al. Daily voluntary exercise enhances pilocarpine-induced saliva secretion and aquaporin 1 expression in rat submandibular glands. FEBS Open Bio. 2017 Dec 7;8(1):85-93.|[2]Yuan XL, et al. Cytotoxicity of pilocarpine to human corneal stromal cells and its underlying cytotoxic mechanisms. Int J Ophthalmol. 2016 Apr 18;9(4):505-11.|[3]Tonta MA, et al. Pilocarpine-induced relaxation of rat tail artery by a non-cholinergic mechanism and in the absence of an intact endothelium. Br J Pharmacol. 1994 Jun;112(2):525-32.BMC Immunol. 2024 Feb 12;25(1):16.|Cell Rep. 2023 Apr 30;42(5):112456.|FASEB J. 2024 Aug 15;38(15):e23878.|Int J Mol Sci. 2023 Apr 12;24(8):7171.|Int J Mol Sci. 2023 Apr 16, 24(8), 7356.|Int J Mol Sci. 2024 Sep 27;25(19):10432.|Life Sci. 2022 Nov 1;308:120942.|Mol Immunol. 2024 Jun 19:172:68-75.|Neurochem Int. 2024 Jan 28:174:105677.|Ocul Surf. 2024 Sep 27:S1542-0124(24)00104-6.|Prog Neurobiol. 2022 Aug 2;102335.|Research Square Preprint. 2023 Apr 13.|Research Square Print. December 16th, 2022.|Acta Pharmacol Sin. 2024 Jul 25.|Brain Res. 2023 Apr 29;148382.|Brain Sci. 2023, 13(2), 262.|Cell Mol Neurobiol. 2020 Oct 15. |Cells. 2024 Oct 1;13(19):1635.|Commun Biol. 2024 Sep 17;7(1):1158.|Epilepsy Res. 2018 May;142:45-52. |Exp Eye Res. 2024 Jul 16:110008.|Food Chem. 30 November 2022, 133593.|Immunity. 2022 Jul 12;S1074-7613(22)00291-6.|Int Immunopharmacol. 2022 Aug 22;111:109152.|Int Immunopharmacol. 2024 Jan 5:128:111485.|J Mol Neurosci. 2020 Nov;70(11):1858-1870.|Neuropharmacology. 2017 May 1;117:238-248.|Neuroscience. 2021 Feb 10;455:212-222.|Research Square Preprint. 2021 Aug.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, protect from light)
• Clinical Information: Launched