Sotorasib isomer
CAT:
804-HY-114277B-01
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Sotorasib isomer
- UNSPSC Description: Sotorasib (AMG-510) isomer is the less active isomer of Sotorasib (AMG-510). AMG-510 is a potent KRAS G12C covalent inhibitor.
- Target Antigen: Others
- Type: Reference compound
- Related Pathways: Others
- Field of Research: Others
- Assay Protocol: https://www.medchemexpress.com/sotorasib-isomer.html
- Purity: 99.09
- Solubility: 10 mM in DMSO|H2O : < 0.1 mg/mL (ultrasonic)
- Smiles: O=C(C=C)N1C[C@H](C)N(C2=NC(N(C(C(C(C)C)=NC=C3)=C3C)C4=C2C=C(F)C(C5=C(O)C=CC=C5F)=N4)=O)CC1.[Peak 2]
- Molecular Weight: 560.59
- References & Citations: [1]Karen Rex, et al. Abstract 3090: In vivo characterization of AMG 510 - a potent and selective KRASG12Ccovalent small molecule inhibitor in preclinical KRASG12Ccancer models. Experimental and Molecular Therapeutics.|[2]Brian A. Lanman, et al.Abstract 4455: Discovery of AMG 510, a first-in-human covalent inhibitor of KRASG12C for the treatment of solid tumors. Cancer Chemistry.|[3]Marwan Fakih, et al, Phase 1 study evaluating the safety, tolerability, pharmacokinetics (PK), and efficacy of AMG 510, a novel small molecule KRASG12Cinhibitor, in advanced solid tumors. Journal of Clinical Oncology.|[4]Canon J, et al. The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity. Nature. 2019 Nov;575(7781):217-223.
- Shipping Conditions: Blue Ice
- Storage Conditions: -20°C, 3 years (Powder)
- Clinical Information: No Development Reported