Eriodictyol

Eriodictyol

• CAS Number: 552-58-9
• UNSPSC Description: Eriodictyol is a flavonoid isolated from the Chinese herb, with antioxidant and anti-inflammatory activity. Eriodictyol induces Nrf2 signaling pathway. Eriodictyol is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 18 nM.
• Target Antigen: DNA/RNA Synthesis; Endogenous Metabolite; Influenza Virus; Keap1-Nrf2
• Type: Natural Products
• Related Pathways: Anti-infection;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;NF-κB
• Applications: COVID-19-immunoregulation
• Field of Research: Infection; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/Eriodictyol.html
• Purity: 99.85
• Solubility: DMSO : 125 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL
• Smiles: O=C1C[C@@H](C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C13
• Molecular Weight: 288.25
• References & Citations: [1]Zhu GF, et al. Eriodictyol, a plant flavonoid, attenuates LPS-induced acute lung injury through its antioxidative and anti-inflammatory activity. Exp Ther Med. 2015 Dec;10(6):2259-2266. Epub 2015 Oct 23.|[2]Jing X, et al. Eriodictyol Attenuates β-Amyloid 25-35 Peptide-Induced Oxidative Cell Death in Primary Cultured Neurons by Activation of Nrf2. Neurochem Res. 2015 Jul;40(7):1463-71.|[3]Václav Zima, et al. Unraveling the Anti-Influenza Effect of Flavonoids: Experimental Validation of Luteolin and its Congeners as Potent Influenza Endonuclease Inhibitors. Eur J Med Chem. 22 August 2020, 112754.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, protect from light)
• Clinical Information: No Development Reported