sn-Glycero-3-phosphocholine

sn-Glycero-3-phosphocholine

• CAS Number: 28319-77-9
• UNSPSC Description: sn-Glycero-3-phosphocholine (Choline Alfoscerate) is a precursor in the biosynthesis of brain phospholipids and increases the bioavailability of choline in nervous tissue. sn-Glycero-3-phosphocholine (Choline Alfoscerate) has significant effects on cognitive function with a good safety profile and tolerability, and is effective in the treatment of Alzheimer's disease and dementia[1][2].
• Target Antigen: Cholinesterase (ChE); Endogenous Metabolite
• Type: Natural Products
• Related Pathways: Metabolic Enzyme/Protease;Neuronal Signaling
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/sn-Glycero-3-phosphocholine.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
• Smiles: O=P(OCC[N+](C)(C)C)(OC[C@H](O)CO)[O-]
• Molecular Weight: 257.223
• References & Citations: [1]Lee SH, et al. Late treatment with choline alfoscerate (l-alpha glycerylphosphorylcholine, α-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairment. Brain Res. 2017 Jan 1;1654(Pt A):66-76.|[2]Traini E, et al. Choline alphoscerate (alpha-glyceryl-phosphoryl-choline) an old choline- containing phospholipidwith a still interesting profile as cognition enhancing agent. Curr Alzheimer Res. 2013 Dec;10(10):1070-9.
• Shipping Conditions: Room Temperature
• Clinical Information: Launched