Sulindac sulfide-d3
CAT:
804-HY-B1786S-01
Size:
1 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Sulindac sulfide-d3
- CAS Number: 250608-66-3
- UNSPSC Description: Sulindac sulfide-d3 is deuterium labeled Sulindac sulfide. Sulindac sulfide is a noncompetitive γ-secretase inhibitor, with an IC50 of 20.2 μM for γ42-secretase activity.
- Target Antigen: Isotope-Labeled Compounds; γ-secretase
- Type: Isotope-Labeled Compounds
- Related Pathways: Neuronal Signaling;Others;Stem Cell/Wnt
- Applications: Neuroscience-Neurodegeneration
- Field of Research: Neurological Disease
- Solubility: 10 mM in DMSO
- Smiles: OC(CC1=C(C)/C(C2=CC=C(F)C=C21)=C/C3=CC=C(C=C3)SC([2H])([2H])[2H])=O
- Molecular Weight: 343.43
- References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Takahashi Y, et al. Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation. J Biol Chem. 2003 May 16;278(20):18664-70.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported