AKT1 (Proto-Oncogene)
CAT:
544-MBS439937-04
Size:
5x 0.1 mg (With BSA & Azide at 0.2mg/mL)
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
AKT1 (Proto-Oncogene)
- Gene Name: [AKT1]
- NCBI Gene ID: 207
- Reactivity: Human. Others not known
- Storage Conditions: Antibody with azide - store at 2 to 8 °C.
Antibody without azide - store at -20 to -80 °C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required. - Specificity: Recognizes a protein of 62kDa, which is identified as AKT1The serine/threonine kinase Akt family contains several members, including Akt1 (also designated PKB or RacPK), Akt2 (also designated PKB? or RacPK-?) and Akt 3 (also designated PKB? or thyoma viral proto-oncogene 3), which exhibit sequence homology with the protein kinase A and C families and are encoded by the c-Akt proto-oncogene. All members of the Akt family have a Pleckstrin homology domain. Akt1 and Akt2 are activated by PDGF stimulation. This activation is dependent on PDGFR-? tyrosine residues 740 and 751, which bind the subunit of the phosphatidylinositol 3-kinase (PI 3-kinase) complex. Activation of Akt1 by insulin or insulin-growth factor-1(IGF-1) results in phosphorylation of both Thr 308 and Ser 473. Akt proteins become phosphorylated and activated in insulin/IGF-1-stimulated cells by an upstream kinase(s), and the activation of Akt1 and Akt2 is inhibited by the PI kinase inhibitor wortmannin.
- Other Gene Names: [AKT1; AKT1; AKT; PKB; RAC; CWS6; PRKBA; PKB-ALPHA; RAC-ALPHA; PKB; RAC; PKB; PKB alpha]
- Short Name: [AKT1]
- Other Product Names: [RAC-alpha serine/threonine-protein kinase; RAC-alpha serine/threonine-protein kinase; RAC-alpha serine/threonine-protein kinase; AKT serine/threonine kinase 1; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha]
- NCBI GI Number: 62241013
- NCBI Accession Number: NP_001014431.1
- NCBI GB Accession Number: NM_001014431.1
- Uniprot Accession Number: P31749