Proteinase 3/PR3 Polyclonal Antibody

Proteinase 3/PR3 Polyclonal Antibody

• Background: Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro. By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration. May play a role in neutrophil transendothelial migration, probably when associated with CD177.
• Synonyms: ACPA,AGP7,C-ANCA,CANCA,MBN,MBT,NP-4,NP4,P29,PR-3,PR3,PRTN3
• Gene ID: 5657
• Swiss Prot: P24158
• Host: Rabbit
• Reactivity: Rat
• Immunogen: Recombinant fusion protein of human Proteinase 3/PR3
• Clonality: Polyclonal
• Isotype: IgG
• Conjugation: Unconjugated
• Applications: WB
• Purification: Affinity purification
• Concentration: 1mg/mL
• Dilution: WB 1:500-1:2000
• Buffer: PBS with 0.01% thiomersal,50% glycerol,pH7.3.
• Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
• Calculated Molecular Weight: 92 kDa
• Observed Molecular Weight: 110kDa