ALIX / PDCD6IP Polyclonal Antibody
CAT:
866-RD86817A-03
Size:
200 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
ALIX / PDCD6IP Polyclonal Antibody
- Background: This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15.
- Synonyms: PDCD6IP,AIP1,ALIX,DRIP4,HP95
- Gene ID: 10015
- Swiss Prot: Q8WUM4
- Host: Rabbit
- Reactivity: Human,Mouse,Rat
- Immunogen: Recombinant fusion protein of human ALIX / PDCD6IP
- Clonality: Polyclonal
- Isotype: IgG
- Conjugation: Unconjugated
- Applications: WB,IF
- Purification: Affinity purification
- Concentration: 1 mg/mL
- Dilution: WB 1:200-1:2000,IF 1:50-1:200
- Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
- Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
- Calculated Molecular Weight: 36kDa
- Observed Molecular Weight: 37KDa