AF488 Anti-Mouse CD274/PD-L1 Antibody[10F.9G2]

AF488 Anti-Mouse CD274/PD-L1 Antibody[10F.9G2]

• Background: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.
• Synonyms: B7-H1, PD-L1,Programmed cell death ligand 1,B7 homolog 1,B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1,
• Gene ID: 60533
• Host: Rat
• Reactivity: Mouse
• Isotype: IgG2b κ
• Conjugation: AF488
• Applications: FCM
• Concentration: 0.5 mg/mL
• Buffer: Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
• Storage Conditions: This product can be stored at 2-8°C for 12 months. Please protect from prolonged exposure to light and do not freeze.