HLA-DOB Polyclonal Antibody
CAT:
866-RD87415A-02
Size:
120 μL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
HLA-DOB Polyclonal Antibody
- Background: HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
- Synonyms: HLA-DOB,DOB,HLA_DOB,major histocompatibility complex,class II,DO beta
- Gene ID: 3112
- Swiss Prot: P13765
- Host: Rabbit
- Reactivity: Human,Mouse,Rat
- Immunogen: Recombinant fusion protein of human HLA-DOB
- Clonality: Polyclonal
- Isotype: IgG
- Conjugation: Unconjugated
- Applications: WB
- Purification: Affinity purification
- Concentration: 1mg/mL
- Dilution: WB 1:500-1:1000
- Buffer: PBS with 0.01% thiomersal,50% glycerol,pH7.3.
- Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
- Calculated Molecular Weight: 28kDa/49kDa
- Observed Molecular Weight: 49kDa