HLA-DPB1 Polyclonal Antibody
CAT:
866-RD90186A-01
Size:
60 μL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
HLA-DPB1 Polyclonal Antibody
- Background: HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
- Synonyms: DPB1,HLA-DP,HLA-DP1B,HLA-DPB,HLA-DPB1,major histocompatibility complex,class II,DP beta 1
- Gene ID: 3115
- Swiss Prot: P04440
- Host: Rabbit
- Reactivity: Mouse
- Immunogen: A synthetic peptide of human HLA-DPB1
- Clonality: Polyclonal
- Isotype: IgG
- Conjugation: Unconjugated
- Applications: WB
- Purification: Affinity purification
- Concentration: 1mg/mL
- Dilution: WB 1:500-1:2000
- Buffer: PBS with 0.01% thiomersal,50% glycerol,pH7.3.
- Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
- Calculated Molecular Weight: 30kDa/33kDa
- Observed Molecular Weight: 33kDa