IMR-1
CAT:
804-HY-100431-03
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
IMR-1
- CAS Number: 310456-65-6
- UNSPSC Description: IMR-1 is a novel class of Notch inhibitor targeting the transcriptional activation with an IC50 of 26 μM. IMR-1 prevents the recruitment of Mastermind-like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth[1].
- Target Antigen: Notch
- Type: Reference compound
- Related Pathways: Neuronal Signaling;Stem Cell/Wnt
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/IMR-1.html
- Purity: 98.95
- Solubility: DMSO : ≥ 100 mg/mL
- Smiles: O=C(OCC)COC1=CC=C(/C=C(SC(N2)=S)\C2=O)C=C1OC
- Molecular Weight: 353.41
- References & Citations: [1]Astudillo L et al. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res. 2016 Jun 15;76(12):3593-603.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported