BECN1 Monoclonal Antibody

BECN1 Monoclonal Antibody

• Background: Beclin-1 (BECN1), also known as ATG6 or VPS30, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. Beclin-1, may play a role in antiviral host defense. It protects against infection by a neurovirulent strain of Sindbis virus. Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. A progressively reduced Beclin-1 expression is reported to correlate with the primary tumor growth of squamous cell carcinoma and adenocarcinoma of the lung. Caspase-mediated cleavage of Beclin 1 promotes crosstalk between apoptosis and autophagy.
• Synonyms: APG6,ATG 6,ATG6,ATG6 autophagy related 6 homolog,Bcl-2-interacting protein beclin,Beclin 1 (coiled coil moesin like BCL2 interacting protein),Beclin 1 autophagy related,Beclin-1,Beclin1,BECN 1,Becn1,BECN1,Coiled coil myosin like BCL2 interacting protein,Coiled-coil myosin-like BCL2-interacting protein,GT197,Protein GT197,VPS 30,VPS30
• CAS Number: 9007-83-4
• Swiss Prot: Q14457
• Host: Mouse
• Reactivity: Human,Mouse,Rat
• Immunogen: Synthetic Peptide of Beclin-1
• Clonality: Monoclonal
• Isotype: IgG
• Conjugation: Unconjugated
• Applications: WB,IHC-p
• Purification: Protein A purification
• Concentration: 1 mg/mL
• Dilution: WB 1:1000-2000, IHC 1:100-200
• Buffer: PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
• Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles.
• Observed Molecular Weight: 60 kDa