MDH1 Polyclonal Antibody

MDH1 Polyclonal Antibody

• Background: This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. Alternatively spliced transcript variants have been found for this gene. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes X and 6.
• Synonyms: MDH1,HEL-S-32,MDH-s,MDHA,MGC:1375,MOR2
• CAS Number: 9007-83-4
• Gene ID: 4190
• Swiss Prot: P40925
• Host: Rabbit
• Reactivity: Human,Mouse,Rat
• Immunogen: Recombinant fusion protein of human MDH1 (NP_005908.1).
• Isotype: IgG
• Conjugation: Unconjugated
• Applications: WB
• Purification: Affinity purification
• Concentration: 1 mg/mL
• Dilution: WB 1:500-1:2000
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles.
• Calculated Molecular Weight: 27 kDa/36 kDa/38 kDa
• Observed Molecular Weight: 36 kDa