GSK3 alpha/beta Polyclonal Antibody

GSK3 alpha/beta Polyclonal Antibody

• Background: Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin. GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3 kinase/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3βGSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus and mammalian development. GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization.
• Synonyms: GSK3A,Glycogen synthase kinase-3 alpha,GSK-3 alpha,Serine/threonine-protein kinase GSK3A,GSK3B,Glycogen synthase kinase-3 beta,GSK-3 beta,Serine/threonine-protein kinase GSK3B
• CAS Number: 9007-83-4
• Swiss Prot: P49840,P49841
• Host: Rabbit
• Reactivity: Human,Mouse,Rat
• Immunogen: Synthesized peptide derived from human GSK3α/β around the non-phosphorylation site of Tyr279/216.
• Clonality: Polyclonal
• Isotype: IgG
• Conjugation: Unconjugated
• Applications: WB,IHC-p,ELISA
• Purification: Affinity purification
• Concentration: 1 mg/mL
• Dilution: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:20000
• Buffer: PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
• Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles.
• Calculated Molecular Weight: 51 kDa
• Observed Molecular Weight: 51,46 kDa