AF488 Anti-Mouse CD122 Antibody

AF488 Anti-Mouse CD122 Antibody

• Background: CD122 is a 70-75 kD IL-2 receptor β chain also known as IL-2Rβ, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rβ chain can combine with either the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. The 5H4 antibody does not block IL-2 binding to the IL-2 receptor. CD122 is expressed on murine, but not human, CD8+ Tregs involved in the maintenance of T cell homeostasis.
• Synonyms: Interleukin-2 receptor subunit beta,Il2rb,IL-2 receptor subunit beta, IL-2R subunit beta,IL-2RB,High affinity IL-2 receptor subunit beta,p70-75,CD122
• CAS Number: 9007-83-4
• Gene ID: 16185
• Swiss Prot: P16297
• Host: Rat
• Reactivity: Mouse
• Clonality: Monoclonal
• Isotype: IgG2a κ
• Conjugation: AF488
• Applications: FCM
• Concentration: 0.5 mg/mL
• Buffer: PBS with 0.05% Proclin300, 1% BSA
• Storage Conditions: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.