PerCP/Cyanine5.5 Anti-Mouse CD22 Antibody

PerCP/Cyanine5.5 Anti-Mouse CD22 Antibody

• Background: The Cy34.1 monoclonal antibody specifically binds to the B-lymphocyte differentiation antigen CD22 on strains having the Lyb-8.2 alloantigen (e.g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, SWR, but not AKR, DBA/1, DBA/2, NZB, PL). CD22 is expressed at high levels on mature peripheral B lymphocytes (follicular and marginal zone), B-1 cells (CD5+ B cells), and plasma cells. It is a member of the Ig gene superfamily and associates with the B-cell antigen receptor. Its sialic acid- binding immunoglobulin-like lectin (siglec) extracellular region mediates B-cell adhesion to ligands on endothelial cells in the bone marrow. Its intracellular domain is phosphorylated after cross-linking of antigen receptor or MHC class II antigen. It is involved in negative regulation of B-cell activation and protection from autoimmunity. B-cell proliferative responses to LPS or anti-mouse Ig µ chain are augmented in the presence of Cy34.1 mAb.
• Synonyms: B-cell receptor CD22,Cd22,B-lymphocyte cell adhesion molecule,BL-CAM,Sialic acid-binding Ig-like lectin 2,Siglec-2,T-cell surface antigen Leu-14,CD22,Lyb-8, Siglec2
• CAS Number: 9007-83-4
• Gene ID: 12483
• Swiss Prot: P35329
• Host: Mouse
• Reactivity: Mouse
• Clonality: Monoclonal
• Isotype: IgG1 κ
• Conjugation: PerCP/Cyanine5.5
• Applications: FCM
• Buffer: PBS with 0.05% Proclin300, 1% BSA
• Storage Conditions: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.