Anti-Phospho-beta-catenin (Ser33/37) Antibody

Anti-Phospho-beta-catenin (Ser33/37) Antibody

• Background: Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22647378, PubMed:22699938, PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity).
• Description: Boster Bio Anti-Phospho-beta-catenin (Ser33/37) Antibody (Catalog # M00004-4). Tested in WB application(s). This antibody reacts with Human.
• Synonyms: Catenin beta-1, Beta-catenin, CTNNB1, CTNNB
• Gene Name: CTNNB1
• UniProt: P35222
• Host: Rabbit
• Reactivity: Human
• Immunogen: This Phospho-beta-catenin (Ser33/37) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 19-41 amino acids from human beta-catenin .
• Clonality: Polyclonal
• Applications: WB
• Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Molecular Weight: 85497 Da
• Components: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
• Storage Conditions: Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Fragment: Rabbit IgG