Mouse CD206/CLEC13D ELISA Kit PicoKine®, Carrier-free

Mouse CD206/CLEC13D ELISA Kit PicoKine®, Carrier-free

• Background: The mannose receptor (Cluster of Differentiation 206, CD206) is a C-type lectin primarily present on the surface of macrophages and immature dendritic cells, but is also expressed on the surface of skin cells such as human dermal fibroblasts and keratinocytes. It is the first member of a family of endocytic receptors that includes Endo180 (CD280), M-type PLA2R, and DEC-205 (CD205). This gene is mapped to 2 A2; 2 10.46 cM. The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.
• Description: Mouse CD206/CLEC13D ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Mrc1 in cell culture supernatants, serum and plasma (heparin, EDTA, citrate). Sensitivity: 50pg/ml. The brand Picokine indicates this is a premium quality ELISA kit. Each Picokine kit delivers precise quantification, high sensitivity, and excellent reproducibility. Only our most reliable and effective kits qualify as Picokine, guaranteeing top-tier results for your assays.
• Synonyms: Macrophage mannose receptor 1; MMR; CD206; Mrc1
• Gene Name: mannose receptor, C type 1
• Gene ID: 17533
• UniProt: Q61830
• Reactivity: Mouse
• Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.
• Immunogen: Expression system for standard: NS0; Immunogen sequence: L20-A1388
• Tissue Specificity: Detected in macrophages.
• Applications: ELISA
• Standard: 50 ng/tube
• Sample Type: cell culture supernatants, serum and plasma (heparin, EDTA, citrate).
• Detection Range: 0.78 ng/ml - 50 ng/ml
• Sensitivity: <50 pg/ml
• Function: Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.
• Components: Description|Quantity Pre-coated 96-well strip microplate|1 Standard|2 vials Biotinylated antibody (100x)|100ul Avidin-Biotin-Peroxidase Complex (100x)|100ul Sample Diluent|30ml Antibody Diluent|12ml Avidin-Biotin-Peroxidase Diluent|12ml Color Developing Reagent (TMB)|10ml Stop Solution|10ml Wash Buffer (25x)|20ml Adhesive plate sealers|4
• Storage Conditions: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)
• Specificity: Natural and recombinant mouse CD206/CLEC13D
• Reproducibility:

  Lots	Lot 1 (pg/ml)	Lot 2 (pg/ml)	Lot 3 (pg/ml)	Lot 4 (pg/ml)	Mean (pg/ml)	Standard Deviation	CV (%)
  Sample 1	1150	1144	1176	1080	1137	35.30	3.1%
  Sample 2	6191	5982	6880	6356	6352	332.27	5.2%
  Sample 3	22279	22618	21731	19374	21500	1267.87	5.8%

  *number of samples for each test n=16.
• : heparin, EDTA or citrate
• Subcellular Location: Cell membrane. Single-pass type I membrane protein. Endosome membrane. Single-pass type I membrane protein.