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Anti-CD59 glycoprotein CD59 Antibody Picoband®, iFluor647 Conjugate

CAT:
519-RP1076-iFluor647
Size:
100 µg
Price:
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For price, please contact [email protected]
  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
Anti-CD59 glycoprotein CD59 Antibody Picoband®, iFluor647 Conjugate - image 1

Anti-CD59 glycoprotein CD59 Antibody Picoband®, iFluor647 Conjugate

  • Background: This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. And this protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. It also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
  • Description: Boster Bio Anti-CD59 glycoprotein CD59 Antibody catalog # RP1076. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
  • Synonyms: CD59 glycoprotein;1F5 antigen;20 kDa homologous restriction factor;HRF-20;HRF20;MAC-inhibitory protein;MAC-IP;MEM43 antigen;Membrane attack complex inhibition factor;MACIF;Membrane inhibitor of reactive lysis;MIRL;Protectin;CD59;CD59;MIC11, MIN1, MIN2, MIN3, MSK21;
  • Gene Name: CD59 glycoprotein
  • Gene ID: 966
  • UniProt: P13987
  • Host: Rabbit
  • Reactivity: Human
  • Cross Reactivity: No cross-reactivity with other proteins
  • Immunogen: E.coli-derived human CD59 recombinant protein (Position: L26-N102). Human CD59 shares 47.1% amino acid (aa) sequence identity with rat CD59.
  • Clonality: Polyclonal
  • Applications: Flow Cytometry,IF,IHC,ICC,WB
  • Purification: Immunogen affinity purified.
  • Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
  • Form: Lyophilized
  • Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
  • Function: Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.
  • Components: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
  • References & Citations: 1. "Entrez Gene: CD59 molecule, complement regulatory protein". 2. Ninomiya H, Sims PJ (1992). "The human complement regulatory protein CD59 binds to the alpha-chain of C8 and to the "b"domain of C9". J. Biol. Chem. 267 (19): 13675–80.
  • Storage Conditions: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.
  • Calculated Molecular Weight: 14177 MW
  • Observed Molecular Weight: 19 kDa
  • Fragment: Rabbit IgG
  • Specificity: No cross reactivity with other proteins.
  • Applications Notes: Western blot, 0.1-0.25 μg/ml
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, By Heat
    Immunocytochemistry/Immunofluorescence, 5μg/ml
    Flow Cytometry (Fixed), 1-3μg/1x106cells
  • Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Soluble form found in a number of tissues.
  • Sequence Similarities: Contains 1 UPAR/Ly6 domain.
  • Protein Name: CD59 glycoprotein