Anti-CD40/Cd40 Antibody Picoband®, FITC Conjugate

Anti-CD40/Cd40 Antibody Picoband®, FITC Conjugate

• Background: This CD40 gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
• Description: Boster Bio Anti-CD40/Cd40 Antibody Picoband® catalog # A00068-1. Tested in ELISA, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
• Synonyms: CD40 molecule ;CD40 molecule, TNF receptor superfamily member 5 ;Tumor necrosis factor receptor superfamily, member 5, isoform CRA_a ;Cd40 ;Tnfrsf5 ;rCG_32260 ;
• Gene Name: CD40 molecule
• Gene ID: 171369
• UniProt: Q4QQW2
• Host: Rabbit
• Reactivity: Mouse,Rat
• Cross Reactivity: No cross-reactivity with other proteins.
• Immunogen: E. coli-derived rat CD40 recombinant protein (Position: V24-R193).
• Clonality: Polyclonal
• Applications: ELISA,WB
• Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
• Form: Lyophilized
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Components: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na₂HPO₄, 0.05mg NaN₃.
• References & Citations: 1. Asimakopoulos, F. A., White, N. J., Nacheva, E. P., Green, A. R. The human CD40 gene lies within chromosome 20q deletions associated with myeloid malignancies. Brit. J. Haemat. 92: 127-130, 1996. 2. Becker, T., Hartl, F.-U., Wieland, F. CD40, an extracellular receptor for binding and uptake of Hsp70-peptide complexes. J. Cell Biol. 158: 1277-1285, 2002.
• Storage Conditions: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.
• Calculated Molecular Weight: 31801 MW
• Observed Molecular Weight: 36 kDa
• Fragment: Rabbit IgG
• Specificity: No cross reactivity with other proteins.
• Applications Notes: Western blot, 0.1-0.5μg/ml
  ELISA, 0.1-0.5μg/ml