Anti-Glucose 6 phosphate isomerase/GPI Antibody Picoband®, HRP Conjugate
CAT:
519-PB10068-HRP
Size:
100 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No

Anti-Glucose 6 phosphate isomerase/GPI Antibody Picoband®, HRP Conjugate
- Background: Glucose-6-phosphate isomerase (GPI), alternatively known as phosphoglucose isomerase (PGI) or phosphohexose isomerase (PHI), is an enzyme that in humans is encoded by the GPI gene on chromosome 19. This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phophsate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants.
- Description: Boster Bio Anti-Glucose 6 phosphate isomerase/GPI Antibody Picoband® catalog # PB10068. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
- Synonyms: Glucose-6-phosphate isomerase;GPI;5.3.1.9;Autocrine motility factor;AMF;Neuroleukin;NLK;Phosphoglucose isomerase;PGI;Phosphohexose isomerase;PHI;Sperm antigen 36;SA-36;GPI;
- Gene Name: Glucose-6-phosphate isomerase
- Gene ID: 2821
- UniProt: P06744
- Host: Rabbit
- Reactivity: Human
- Cross Reactivity: No cross-reactivity with other proteins.
- Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human GPI, different from the related mouse and rat sequences by sixteen amino acids.
- Clonality: Polyclonal
- Tissue Specificity: Expressed in heart, spleen, testis and, to a lower extent, in thymus and peripheral blood leukocytes. Weakly expressed in lung, placenta, colon and small intestine.
- Applications: WB
- Purification: Immunogen affinity purified.
- Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
- Form: Lyophilized
- Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
- Function: Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons. .
- Components: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
- References & Citations: 1. Haga A, Niinaka Y, Raz A (2000). "Phosphohexose isomerase/autocrine motility factor/neuroleukin/maturation factor is a multifunctional phosphoprotein.". Biochim. Biophys. Acta 1480(1-2): 235–44. 2. Kugler W, Lakomek M (March 2000). "Glucose-6-phosphate isomerase deficiency". Baillieres Best Pract. Res. Clin. Haematol. 13 (1): 89–101.
- Storage Conditions: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.
- Calculated Molecular Weight: 63147 MW
- Observed Molecular Weight: 63 kDa
- Fragment: Rabbit IgG
- Specificity: No cross reactivity with other proteins.
- Applications Notes: Western blot, 0.1-0.5μg/ml, Human
- Subcellular Location: Cytoplasm . Secreted .
- Protein Name: Glucose-6-phosphate isomerase